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Holmes and Watson are visited at 221B Baker Street by Ann Brandon ( Ida Lupino).

I admire it so much I'd like to present it, pickled in alcohol, to the London Medical Society." "It would make an impressive exhibit," replies Moriarty. Holmes remarks, "You have a magnificent brain, Moriarty. The picture begins with Moriarty and Sherlock Holmes verbally sparring on the steps outside the Old Bailey, where Moriarty has just been acquitted on a charge of murder owing to lack of evidence. The play featured a very young Charlie Chaplin in one of his very first acting roles during its first London production, playing the character of Billy, who, in this movie, is played by Terry Kilburn. The film was supposedly based on the stage play by William Gillette, though little of the play's original plot remains aside from the Holmes/Moriarty conflict. The film co-stars George Zucco as Holmes's nemesis, Professor Moriarty, and follows Holmes and Watson as they attempt to foil Moriarty’s plans to target a wealthy family and steal the Crown Jewels. The Adventures of Sherlock Holmes is the final film in the series to be released by 20th Century Fox and the final to be set in the Victorian period of Doyle’s stories (all subsequent films would be released by Universal Pictures and set in contemporaneous times (i.e. Released by 20th Century Fox, the film is the second of fourteen Sherlock Holmes films produced between 19, starring Basil Rathbone as Holmes and Nigel Bruce as Dr. Although claiming to be an adaptation of the 1899 play Sherlock Holmes by William Gillette, the film bears little resemblance to the play. The Adventures of Sherlock Holmes (released theatrically as Sherlock Holmes in the United Kingdom) is a 1939 American mystery adventure film based on Sir Arthur Conan Doyle's Sherlock Holmes detective stories.